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A Neutral Lipophilic Technetium-99m Complex for Regional Cerebral Blood Flow Imaging

The Squibb Institute for Medical Research, New Brunswick, New Jersey

Correspondence: For reprints contact: Rama K. Narra, PhD, The Squibb Institute for Medical Research, P.O. Box 191. New Brunswick, NJ 08903-0191.

ABSTRACT

Technetium-99m-DMG-2MP (Chloro[bis{2,3-butanedionedioxime (1–)–0} {2,3-butanedionedioximato (2–)–N,N',N'',N''',N'''',N'''''} (2-methylpropyl borato (2–)) technetium]), also known as SQ 32097 is a member of a family of neutral lipophilic compounds generally known as boronic acid adducts of technetium dioxime complexes (BATOs). After i.v. administration, the concentration of [^99mTc]DMG-2MP in various regions of the brain appears to be proportional to blood flow. In rats, 1.1% ID was in the brain at 5 min postinjection when the blood contained <3% ID. Over 24 hr excretion was 59% in the feces and 23% in the urine. The activity in monkey brain at 5 min was 2.8% ID and it cleared with a t_1/2 of 86 min. Autoradiographs of monkey brain sections showed excellent regional detail with a gray/white ratio of 3.6 at 10 min. The distribution of [^99mTc]DMG-2MP in the monkey brain corresponds to the known cytoarchitectural pattern of cerebral glucose metabolism. The properties of [^99mTc]DMG-2MP make it a potentially useful agent for cerebral perfusion imaging in man.