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Validation Studies of Iodine-123-Iodoamphetamine as a Cerebral Blood Flow Tracer Using Emission Tomography

Cerebrovascular Research Center, Departments of Neurology and Radiology, University of Pennsylvania, Philadelphia, Pennsylvania

Correspondence: For reprints contact: Joel H. Greenberg, PhD, Cerebrovascular Research Center, 429 Johnson Pavilion, University of Pennsylvania, Philadelphia, PA 19104.

ABSTRACT

We studied the radioisotope iodine-123-iodoamphetamine ([¹²³I]IMP) and its performance in single-photon emission computed tomographic (SPECT) studies of cerebral blood flow (CBF). In seven normal volunteers, IMP/SPECT CBF measurements were calculated using a two-compartment model and were compared with the results of CBF measurements utilizing (O¹⁵)-H₂O and positron emission tomography (PET). Calculated mean PET CBF was 57.6 ml/100g/min while the SPECT CBF value was 47.3 ml/100 g/min. The response of IMP/SPECT CBF to alterations in arterial PaCO₂ was studied in hypo-, eu- and hypercarbic subjects. SPECT CBF values showed a reactivity of 1.03 ml/100 g/min per mmHg P_aC0₂ change.These results show that the IMP/SPECT CBF technique may be used for quantitative imaging of CBF in man. They provide further support for IMP as a CBF tracer.

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