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Effect of Regional Myocardial Ischemia on Sympathetic Nervous System as Assessed by Fluorine-18-Metaraminol

Department of Internal Medicine, Division of Nuclear Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: Markus Schwaiger, MD, The University of Michigan Medical Center, 1500 E. Medical Center Dr., UH B1 G505, Box 0028, Ann Arbor, MI 48109-0028.

ABSTRACT

With the introduction of radiolabeled catecholamine analogues, the noninvasive evaluation of the cardiac sympathetic nervous system has become possible. This study evaluated the effect of regional ischemia on myocardial retention of the new norepinephrine analogue 6-[¹⁸F] fluorometaraminol (FMR) in the open chest dog model. Six dogs were injected intravenously with FMR following 30-min occlusion of the left anterior descending artery. Six sham animals served as control group. Regional myocardial blood flow as determined by microspheres decreased 87% during ischemia (p < 0.01), but was not significantly different from control myocardium following reperfusion. Regional myocardial ¹⁸F activity as determined postmortem was significantly reduced in reperfused myocardium (–34%), which paralleled an 18% reduction of tissue norepinephrine concentration. Thus, short time periods of coronary occlusion affect neuronal function indicating the sensitivity of the sympathetic nerve terminals to ischemia. FMR provides a new tracer approach for the characterization of neuronal integrity in postischemic myocardium.

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