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Wiener Filtering Improves Quantification of Regional Myocardial Perfusion with Thallium-201 SPECT

Division of Cardiology, Department of Medicine, and the Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Jonathan M. Links, PhD, Division of Nuclear Medicine, Johns Hopkins Medical Institutions, 615 N. Wolfe St., Baltimore, MD 21205-2179.

ABSTRACT

Quantitation of myocardial perfusion with thallium-201 (²⁰¹Tl) SPECT is limited by finite resolution and image noise. This study examined whether Wiener filtering could improve quantitation of the severity of myocardial perfusion deficits. In 19 anesthetized dogs, adjustable stenoses were placed on the left anterior descending (LAD, n=12) or circumflex (LCx, n=7) arteries. Thallium-201 SPECT images were acquired during maximal coronary vasodilation with dipyridamole, and simultaneous measurements of myocardial blood flow were made with microspheres. The relationship between SPECT and microsphere flow deficits in the LAD region was significantly better (p<0.05) with Wiener filtering (Y=0.90X + 0.03, r=0.78) than with conventional Hanning filtering (Y=0.66X + 0.34, r=0.61). Similarly, in the LCx region the relationship between SPECT and microsphere perfusion deficits was better (p<0.01) with the Wiener filter (Y=0.91X + 0.07, r=0.66) than with the Hanning filter (Y=0.36X + 0.50, r=0.40). Wiener filtering improves quantitation of the severity regional myocardial perfusion deficits, allowing better assessment of the functional significance of coronary artery stenoses.

FOOTNOTES

^* Dr. Jeremy is an Overseas Research Fellow of the National Heart Foundation of Australia and recipient of a Telectronics Travelling Fellowship from the Royal Australasian College of Physicians.

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