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Iodine-123-Metaiodobenzylguanidine Scintigraphy in Patients with Chemodectomas of the Head and Neck Region

Departments of Diagnostic Radiology (Division of Nuclear Medicine), Otolaryngology, Internal Medicine (Division of Endocrinology), and Chemical Pathology, University Hospital Leiden, The Netherlands

Correspondence: For reprints contact: A.P.G. van Gils, MD, Dept. of Diagnostic Radiology, University Hospital Leiden, Building 1, C4-Q, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

ABSTRACT

While studying the uptake of iodine-123-metaiodobenzyl-guanidine ([¹²³I]MIBG) in chemodectomas, we coincidentally detected catecholamine secreting tumors in 5 out 14 patients. In three of these cases, a norepinephrine secreting abdominal paraganglioma was subsequently removed. One patient had a norepinephrine secreting chemodectoma and one had a dopamine secreting the modectoma. Prior to [¹²³I]MIBG imaging and urinary catecholamine measurements, endocrine activity was suspected in only one of these five patients. Apart from these five cases, two other patients showed elevated catecholamine secretion and abnormal abdominal [¹²³I] MIBG concentrations. However, these two patients were not surgically explored, because of normal computed tomography (CT) and magnetic resonance (MRI) studies. We suspect that catecholamine-secreting tumors are more common in patients with chemodectomas than is assumed in the literature, and we therefore recommend urinary catecholamine screening for all patients with chemodectomas. In case of elevated catecholamine secretion, MIBG scintigraphy is indicated.

This article has been cited by other articles:

				A. B. Rao, K. K. Koeller, and C. F. Adair From the Archives of the AFIP: Paragangliomas of the Head and Neck: Radiologic-Pathologic Correlation RadioGraphics, November 1, 1999; 19(6): 1605 - 1632. [Abstract] [Full Text] [PDF]