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The Utility of Cerebral Blood Flow Imaging in Patients with the Unique Syndrome of Progressive Dementia with Motor Neuron Disease

Departments of Radiology and Psychiatry, Miyazaki Medical College, Miyazaki, Japan

Correspondence: For reprints contact: Takashi Ohnishi, Department of Radiology, Miyazaki Medical Collage, 5200 Ohaza Kihara Kiyotake-cho, Miyazaki-gun, Miyazaki-ken, 889-16 Japan.

ABSTRACT

Two patients presenting with progressive dementia coupled with motor neuron disease underwent brain SPECT using N-isopropyl-p iodine-123-iodoamphetamine ([¹²³I]IMP). The characteristic clinical features of progressive dementia and motor neuron disease were noted. IMP SPECT also revealed reduced uptake in the bilateral frontal and temporal regions, with no reduction of uptake in the parietal, parietal-occipital regions. We conclude that IMP SPECT has potential for the evaluation of progressive dementia with motor neuron disease.