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Iodine-123-HIPDM Lung Imaging in Pulmonary Vein-Banded Pulmonary Hypertension

VA and University of Kentucky Medical Centers, Lexington, Kentucky

Correspondence: For reprints contact: Wei-Jen Shih, Div. of Nuclear Medicine, Dept. of Diagnostic Radiology, VA Medical Center and Univ. of Kentucky Medical Center, Lexington, KY 40536.

ABSTRACT

To evaluate the use of N,N,N'-trimethyl-N,-[2-hydroxy-3-methyl-5 iodobenzyl-1, 3 propanediamine iodine-123 (HIPDM) in lung imagings for the diagnosis of individual pulmonary vein stenosis, 14 single-pulmonary vein-banded rats underwent lung imaging. After i.v. injection of 250–300 µCi [¹²³I]HIPDM lung images were recorded at 2 min by a gamma camera interfaced with a PDP computer. Banded lung demonstrated higher [¹²³I]HIPDM radioactivity than that of nonbanded lungs. The activity ratio of banded-to-nonbanded lungs ranged from 4.0 to 1.22 (average 1.62). Technetium-99m-macroaggregated albumin (MAA) lung images showed decreased perfusion in banded lung, and normal perfusion in the nonbanded lung. Post-mortem microscopic changes in pulmonary arteries and veins were compatible with the elevated pulmonary artery and venous pressure in vein-banded lung. Whether the high uptake of [¹²³I]HIPDM in banded lungs relates to endothelial receptors for HIPDM is unknown. Nevertheless, the finding of high lung uptake in banded lung in [¹²³I]HIPDM lung imaging may be potentially used to diagnose individual pulmonary vein stenosis.