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Quantitative Assessment of Blood Flow in Pediatric Recipients of Renal Transplants

The Hospital for Sick Children, Toronto, Canada and Hammersmith Hospital, London, England

Correspondence: For reprints contact: Dr. Judith M. Ash, Department of Radiology, The Hospital for Sick children, 555 University Ave.,Toronto, Ontario, Canada M5G 1X8.

ABSTRACT

We applied a renal blood flow (RBF) quantification technique to pediatric data, which depends minimally on bolus shape, uses a conventional radiopharmaceutical ^99mTc-DTPA, and generates a value for RBF as a percentage of cardiac output (RBF/CO). Mean RBF was 16.9% (±4.8) for normal transplants, 13.1% (±2.9) for transplants undergoing mild-to-moderate chronic rejection, 7.9% (±1.3) for those with mild acute rejection and 3.3% (±1.4) for those with moderate-to-severe acute rejection. Very low blood flow values within 24 hr following transplantation may have prognostic significance. Patients who required transplant-nephrectomy had significantly lower RBF/CO values than children who retained their allograft.