HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ramanna, L. Articles by Rosen, G. Search for Related Content PubMed PubMed Citation Articles by Ramanna, L. Articles by Rosen, G.

Thallium-201 Scintigraphy in Bone Sarcoma: Comparison with Gallium-67 and Technetium-MDP in the Evaluation of Chemotherapeutic Response

Department of Nuclear Medicine, Cedars-Sinai Medical Center, Los Angeles, California
Department of Pathology, UCLA Center for the Health Sciences, Los Angeles, California
Cedars-Sinai Comprehensive Cancer Center, Los Angeles, California

Correspondence: For reprints contact: Lalitha Ramanna, MD, Department of Nuclear Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048.

ABSTRACT

This study attempts to characterize thallium-201 (²⁰¹Tl) uptake in patients with bone and soft-tissue sarcoma and to compare these findings with gallium-67 (⁶⁷Ga) and bone scintigraphy with emphasis on evaluating tumor viability before and after chemotherapy. Thirty-eight patients with surgically-proven sarcomas were evaluated. All patients had gallium and thallium studies. Nineteen patients underwent pre- and post-chemotherapy thallium and evaluation. Seven patients also had technetium-99m-MDP (^99mTc-MDP) bone scintigraphy comparisons. Pathologic changes pre- and post-chemotherapy were graded on the basis of %tumor necrosis as defined histologically. Scintigraphic comparisons demonstrated a high degree of correlation with ²⁰¹TI and poor correlation with ^99mTc-MDP. Thallium-201 was superior to ^99mTc-MDP and ⁶⁷Ga in predicting tumor response to chemotherapy as determined by %tumor necrosis determined histologically. Gallium was superior to Tc-MDP in predicting response to chemotherapy. However, both ⁶⁷Ga and ^99mTc-MDP appear to be affected by factors other than tumor activity.

This article has been cited by other articles:

				N. Marina, M. Gebhardt, L. Teot, and R. Gorlick Biology and Therapeutic Advances for Pediatric Osteosarcoma Oncologist, July 1, 2004; 9(4): 422 - 441. [Abstract] [Full Text] [PDF]

				O. Israel, M. Mekel, R. Bar-Shalom, R. Epelbaum, N. Hermony, N. Haim, E. J. Dann, A. Frenkel, M. Ben-Arush, and D. Gaitini Bone Lymphoma: 67Ga Scintigraphy and CT for Prediction of Outcome After Treatment J. Nucl. Med., October 1, 2002; 43(10): 1295 - 1303. [Abstract] [Full Text] [PDF]

				W. H. Meyer, C. B. Pratt, C. A. Poquette, B. N. Rao, D. M. Parham, N. M. Marina, A. S. Pappo, H. H. Mahmoud, J. J. Jenkins, J. Harper, et al. Carboplatin/Ifosfamide Window Therapy for Osteosarcoma: Results of the St Jude Children's Research Hospital OS-91 Trial J. Clin. Oncol., January 1, 2001; 19(1): 171 - 182. [Abstract] [Full Text] [PDF]

				P. L. Jager, B. E. C. Plaat, E. G. E. de Vries, W. M. Molenaar, W. Vaalburg, D. A. Piers, and H. J. Hoekstra Imaging of Soft-Tissue Tumors Using L-3-[Iodine-123]Iodo-{{alpha}}-methyl-tyrosine Single Photon Emission Computed Tomography: Comparison with Proliferative and Mitotic Activity, Cellularity, and Vascularity Clin. Cancer Res., June 1, 2000; 6(6): 2252 - 2259. [Abstract] [Full Text]