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Mucociliary Clearance and Transport in Bronchiectasis: Global and Regional Assessment

Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University, Seiryoumachi, Sendai, Japan

Correspondence: For reprints contact: Toyoharu Isawa, MD, Department of Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University, 4-15 Seiryoumachi, Aoba-ku, Sendai 980, Japan.

ABSTRACT

Global and regional mucociliary clearance and transport in the lungs was studied in 20 patients with bronchiectasis by radioaerosol inhalation lung cine-scintigraphy and the quantitative analysis following inhalation of ultrasonically-generated ^99mTc-tagged human serum albumin aerosol (mass median diameter; 1.93 µm with geometric s.d. of 1.52). In bronchiectatic lung regions, deposition of inhaled aerosol was diminished or inhomogeneous. Transport of inhaled radioactivity from the bronchiectatic regions was deranged in 95% of the patients (19/20). The following abnormal mucous transport patterns were regionally observed; stasis in 12 of the 20 patients (12/20), regurgitation or reversed transport in 14/20, straying in 8/20, spiral or zigzag transport in 1/20, and/or various combinations of these four abnormal transport patterns. When coughs occurred, regurgitation and stray became more marked in the bronchiectatic regions. These regional abnormalities in mucoaliary transport seem to be responsible for the development of infections and hemoptysis in the bronchiectatic regions.

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