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Utility of Gallium Imaging of the Kidneys in Diagnosing Primary Amyloid Nephrotic Syndrome

From the Dysproteinemia Clinic and the Section of Nuclear Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Correspondence: For reprints contact: Morie A. Gertz, MD, Dysproteinemia Clinic, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.

ABSTRACT

We undertook a study to determine the value of gallium imaging of the kidneys in patients who had primary amyloidosis that was manifest clinically by nephrotic syndrome. We studied 28 patients with gallium-67 (⁶⁷Ga) citrate scans performed 48 hr after injection. Intense (3+ to 4+) uptake was noted in both kidneys in 25 of 28 patients. Renal amyloidosis should be considered in the differential diagnosis when diffuse bilateral renal uptake of [⁶⁷Ga] citrate is seen in the setting of nephrotic syndrome. Gallium uptake did not differentiate amyloid nephrotic syndrome from other causes of nephrotic syndrome. Renal gallium uptake showed a weak correlation with 24-hr urine protein excretion (p = 0.06).