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Radioimmunoscintigraphy Using Iodine-131-Anti-CEA Monoclonal Antibodies and Thallium-201 Scintigraphy in Medullary Thyroid Carcinoma: A Case Report

Division of Tumor Biology and Department of Nuclear Medicine, Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam, The Netherlands

Correspondence: For reprints contact: C. A. Hoefnagel, Dept. of Nuclear Medicine, Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands.

ABSTRACT

This case report demonstrates the use of thallium-201 (²⁰¹Tl) scans versus iodine-131- (¹³¹I) anti-CEA F(ab')₂ scans in a patient with high serum CEA levels due to metastases of medullary thyroid carcinoma in the suprarenal region and sacroiliacal region. Scintigraphy using monoclonal antibodies directed against CEA showed a higher tumor uptake (0.26% dose and 0.64% dose, respectively) than a thallium scan and is believed to be promising for future radiotherapeutic applications.

FOOTNOTES

^* Current address: Academical Medical Center, Amsterdam, The Netherlands.