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Myocardial Uptake of Indium-111-Labeled Antimyosin in Acute Subendocardial Infarction: Clinical, Histochemical, and Autoradiographic Correlation of Myocardial Necrosis

Departments of Nuclear Medicine and Medicine (Division of Cardiology), University of Massachusetts Medical Center, Worcester, Massachusetts

Correspondence: For reprints contact: Robert C. Hendel, MD, Section of Cardiology, Northwestern University Medical School, 250 E. Superior St., Chicago, IL 60611.

ABSTRACT

Indium-111-labeled antimyosin has been utilized in the diagnosis and localization of acute transmural myocardial infarction. The present report describes a patient who presented with a massive subendocardial infarction. Two days after the injection of antimyosin, the patient's clinical status markedly deteriorated and he expired. Postmortem examination demonstrated severe three-vessel coronary artery disease with extensive myocyte death in the endocardium. Autoradiography and histochemical staining of the prosected heart demonstrated high correlation for myocardial necrosis and corresponded to clinical evidence for diffuse subendocardial infarction.