HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wahl, R. L. Articles by Hutchins, G. D. Search for Related Content PubMed PubMed Citation Articles by Wahl, R. L. Articles by Hutchins, G. D.

The Potential of 2-Deoxy-2[¹⁸F]Fluoro-D-Glucose (FDG) for the Detection of Tumor Involvement in Lymph Nodes

Division of Nuclear Medicine, Departments of Hematology/Oncology, Internal Medicine, Radiology, and Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: Richard L. Wahl, MD, University of Michigan Medical Center, Internal Medicine/Nuclear Medicine, 1500 East Medical Center Dr., B1G505, Ann Arbor, MI 48109-0028.

ABSTRACT

To assess the potential of FDG for PET imaging of nodal tumor metastases, we evaluated its uptake into normal lymph nodes, tumor-involved lymph nodes, and subcutaneous tumor xenografts in rodents. Normal lymph nodes in mice and rats accumulate FDG moderately, developing node/blood ratios of 1.3–11.9/1 at 2 hr following i.v. injection. By contrast, FDG given subcutaneously to healthy Sprague Dawley rats developed very high normal draining lymph node/blood ratios (272/1) versus 7.7/1 by i.v. injection. In nude mice, subcutaneous human ovarian cancer xenografts had 1.27-fold more uptake relative to blood than did normal popliteal lymph nodes. Subcutaneous tumor xenografts of rat breast cancer developed tumor/normal node uptake ratios of 4.91 ± 0.43/1 and tumor/blood ratios of 6.6 ± 0.9 at 2 hr postinjection. Mouse nodes involved with 38C13 murine B-cell lymphoma had mean node/blood ratios of 42.9 ± 6.7/1 and tumored node/normal lymph node uptake of 6.3/1. Thus, FDG given intravenously but not subcutaneously (due to high normal nodal uptake) has potential as an agent for the detection of metastatic tumors in regional lymph nodes using PET scanning.

This article has been cited by other articles:

				T. M. Blodgett, C. C. Meltzer, and D. W. Townsend PET/CT: Form and Function Radiology, February 1, 2007; 242(2): 360 - 385. [Abstract] [Full Text] [PDF]

				U. Guller, E. Nitzsche, H. Moch, and M. Zuber Is Positron Emission Tomography an Accurate Non-invasive Alternative to Sentinel Lymph Node Biopsy in Breast Cancer Patients? J Natl Cancer Inst, July 16, 2003; 95(14): 1040 - 1043. [Full Text] [PDF]

				K. Kim, S. J. Park, B.-T. Kim, K. S. Lee, and Y. M. Shim Evaluation of lymph node metastases in squamous cell carcinoma of the esophagus with positron emission tomography Ann. Thorac. Surg., January 1, 2001; 71(1): 290 - 294. [Abstract] [Full Text] [PDF]

				T. Higashi, S. J. Fisher, R. S. Brown, K. Nakada, G. L. Walter, and R. L. Wahl Evaluation of the Early Effect of Local Irradiation on Normal Rodent Bone Marrow Metabolism Using FDG: Preclinical PET Studies J. Nucl. Med., December 1, 2000; 41(12): 2026 - 2035. [Abstract] [Full Text] [PDF]