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Metabolism of ß-Methyl-Heptadecanoic Acid in the Perfused Rat Heart and Liver

Departments of Biochemistry and Nutrition, University of Montreal, Montreal, Canada
Division of Nuclear Medicine, Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: Henri Brunengraber, Research Center, Notre-Dame Hospital, Montreal, QC, H2L 4M1, Canada.

ABSTRACT

The metabolism of ß-methyl-[1-¹⁴C]heptadecanoic acid, a potential myocardial imaging agent, was investigated in perfused hearts and livers from rats. Hepatic uptake is 4.5 times greater than cardiac uptake. In the heart, 66% of ß-methyl-heptadecanoic acid metabolism occurs via omega-oxidation, 33% by esterification and <1% via alpha-oxidation. In contrast, 53% of hepatic metabolism of ß-methyl-heptadecanoic acid occurs via alpha-oxidation, 27% via omega-oxidation, and 20% via esterification. Perfusion of hearts and livers with concentrations of ß-methyl-heptadecanoic acid 100 to 1000 times greater than that used for myocardial imaging does not alter any of the physiological and biochemical parameters measured. In the perfused liver, 3-methyl-[1-¹⁴C]glutarate was identified as the principal hydrosoluble catabolite of ß-methyl-heptadecanoic acid.

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