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N-[¹⁸F]Fluoroacetyl-D-glucosamine: A Potential Agent for Cancer Diagnosis

Department of Radiology and Nuclear Medicine, Research Institute for Tuberculosis and Cancer, Tohoku University
Department of Pharmacology, Research Institute for Tuberculosis and Cancer, Tohoku University
Cyclotron and Radioisotope Center, Tohoku University
Radioisotope Laboratory Section, Research Institute for Tuberculosis and Cancer, Tohoku University, Seiryocho, Japan
Division of Clinical Research, National Institute of Radiological Science, Chiba, Japan

Correspondence: For reprints contact: Kazuo Kubota, MD, PhD, Department of Radiology and Nuclear Medicine, Research Institute for Tuberculosis and Cancer, Tohoku University, 4-1 Seiryocho, Aoba-Ku, Sendai 980, Japan.

ABSTRACT

Positron labeled substrates such as sugars, amino acids, and nucleosides have been investigated for the in-vivo evaluation of biochemical processes in cancerous tissue. Hexosamines are obligatory structural components of many biologically important macromolecules, including membrane glycoproteins and mucopolysaccharide. We evaluated a new synthesized pharmaceutical, N-[¹⁸F]fluoroacetyl-D-glucosamine (¹⁸F-FAG), which is a structural analog of N-acetyl-D-glucosamine. C3H/HeMsNRS mice bearing spontaneous hepatomas were used for the tissue distribution study. At 60 min after injection, high uptakes were found in tumor (5.16, mean value of %dose/g), liver (3.71), and kidney (3.27). The tumor uptake of ¹⁸F-FAG showed the highest value in all tissues. In the PET study, VX-2 carcinoma of the rabbit was clearly visualized. Our preliminary results suggest that ¹⁸F-FAG has potential as a new agent for tumor imaging.