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The Journal of Nuclear Medicine Vol. 31 No. 10 1635-1640
© 1990 by Society of Nuclear Medicine
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A New Myocardial Imaging Agent: Synthesis, Characterization, and Biodistribution of Gallium-68-BAT-TECH

H. F. Kung, B. L. Liu, D. Mankoff, M. P. Kung, J. J. Billings, L. Francesconi and A. Alavi

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania

Correspondence: For reprints contact: Hank F. Kung, PhD, Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104.

ABSTRACT

In order to develop a new myocardial perfusion agent for positron emission tomography (PET), a new lipid-soluble gallium complex was evaluated. Synthesis, radiolabeling, characterization, and biodistribution of a unique gallium complex, [67Ga]BAT-TECH (bis-aminoethanethiol-tetraethyl-cyclohexyl), are described. The complex formation between Ga+3 and BAT-TECH ligand is simple, rapid, and of high yield (≥95%). This process is amenable to kit formulation. The complex has a net charge of +1 and a Ga/ligand ratio of 1:1. Biodistribution in rats shows high uptake in the heart as well as in the liver. When [68Ga] BAT-TECH was injected into a monkey, the heart and liver are clearly delineated by PET imaging, suggesting that this complex may be a possible tracer for myocardial perfusion imaging.




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G. L. Griffiths, C.-H. Chang, W. J. McBride, E. A. Rossi, A. Sheerin, G. R. Tejada, H. Karacay, R. M. Sharkey, I. D. Horak, H. J. Hansen, et al.
Reagents and Methods for PET Using Bispecific Antibody Pretargeting and 68Ga-Radiolabeled Bivalent Hapten-Peptide-Chelate Conjugates
J. Nucl. Med., January 1, 2004; 45(1): 30 - 39.
[Abstract] [Full Text] [PDF]


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Copyright © 1990 by the Society of Nuclear Medicine.