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Regional Cerebral Blood Flow Imaging: A Quantitative Comparison of Technetium-99m-HMPAO SPECT with C¹⁵O₂ PET

Department of Bio-Medical Physics and Bio-Engineering, Aberdeen Bio-Medical Imaging Cyclotron Centre
Department of Mental Health, University of Aberdeen and Grampian Health Board
Department of Nuclear Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland

Correspondence: For reprints contact: Dr. Howard Gemmell, Department of Bio-Medical Physics, University of Aberdeen, Foresterhill, Aberdeen AB9 2ZD, Scotland, UK.

ABSTRACT

The aim of this study was to compare technetium-99m-hexamethylpropyleneamineoxime (^99mTc-HMPAO) single-photon emission computed tomography (SPECT) with regional cerebral blood flow (rCBF) imaging using positron emission tomography (PET). As investigation of dementia is likely to be one of the main uses of routine rCBF imaging, 18 demented patients were imaged with both techniques. The PET data were compared quantitatively with three versions of the SPECT data. These were, first, data normalized to the SPECT cerebellar uptake, second, data linearly corrected using the PET cerebellar value and, finally, data Lassen corrected for washout from the high flow areas. Both the linearly-corrected (r = 0.81) and the Lassen-corrected (r = 0.79) HMPAO SPECT data showed good correlation with the PET rCBF data. The relationship between the normalized HMPAO SPECT data and the PET data was nonlinear. It is not yet possible to obtain rCBF values in absolute units from HMPAO SPECT without knowledge of the true rCBF in one reference region for each patient.

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