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Comparative Myocardial Extraction of Two Technetium-Labeled BATO Derivatives (SQ30217, SQ32014) and Thallium

Department of Nuclear Medicine, and Department of Medicine, Cardiology, University of Massachusetts Medical Center, Worcester, Massachusetts

Correspondence: For reprints contact: Jeffrey Leppo, MD, Dept. of Nuclear Medicine, University of Massachusetts Medical Center, 55 Lake Ave. North, Worcester, MA 01655.

ABSTRACT

The transcapillary exchange of a new dass of ^99mTc-labeled compounds (BATO) were compared to ²⁰¹Tl in isolated, blood perfused rabbit hearts. During variable blood flow (0.15–2.44 ml/min/g), peak and net extraction (E_max and E_net, respectively), and capillary permeability-surface area product (PS_cap) were determined with paired indicator-dilution techniques. Serial bolus injections of ²⁰¹Tl, [¹¹¹In]albumin, and [^99mTc]BATO; chloro[tris(cyclohexanedionedioxime)methyl boronic acid]Tc (SQ30217, n = 8) and a hydroxy-substituted derivative (SQ32014, n = 5) were given to a total of 13 hearts. Mean (± s.d.) SQ30217 E_max and E_net were 0.72 ± 0.09 and 0.55 ± 0.18, respectively, which were higher than thallium values of 0.57 ± 0.10 and 0.46 ± 0.17 (p < 0.03). Mean SQ30217 PS_cap was 1.1 ± 0.4 ml/min/g and was also higher than corresponding thallium determinations (0.7 ± 0.3; p < 0.001). SQ32014 E_max, E_net, and PS_cap were all significantly less than thallium values (p <0.001). Thallium and SQ30217 values for E_max and PS_cap were closely correlated with blood flow (r 0.73), whereas those for SQ32014 were weakly correlated (r = 0.09). A small clinical pilot study (n=3) was performed, which showed that SQ32014 was a poor myocardial perfusion agent in man. In summary, transcapillary exchange of SQ30217 is greater than thallium, which in turn, is greater than SQ32014. Therefore, SQ30217 appears to have good clinical potential, but SQ32014 does not.

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