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Imaging of Soft-Tissue Sarcomas with Indium-111-Labeled Monoclonal Antimyosin Fab Fragments

Department ofClinical Chemistry, Division of Nuclear Medicine, Department of Radiotherapy and Oncology, and Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland

Correspondence: For reprints contact: Kalevi J.A. Kairemo, MD, MSc(Eng), Div. of Nuclear Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, SF-00290 Helsinki, Finland.

ABSTRACT

Some soft-tissue sarcomas contain intracellular myosin. We therefore studied the possibility of localizing various soft-tissue sarcomas with ¹¹¹In-labeled monoclonal antibody Fab fragments binding specifically to myosin, assuming that damage to the cell membrane could expose intracellular myosin. Nineteen patients with different types of soft-tissue sarcomas were studied. Eighteen patients were found to have abnormal antibody uptakes. Antibody uptake was not observed in an additional patient operated for a benign tumor (gastric leiomyoma). The immunoscintigraphy results were generally in good agreement with those of other radiologic findings (computed tomography, ultrasound, magnetic resonance imaging). Surprisingly, the immunohistochemistry results showed that tumors not stainable for myosin can also be imaged with antimyosin. Thus, the mechanism of antibody uptake does not seem to be related entirely to specific antigen recognition. Irrespective of the exact mechanism for the uptake of labeled antibody this method appears to be useful for localizing soft-tissue sarcomas.

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