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Technetium-99m HM-PAO-Labeled Leukocytes in Detection of Inflammatory Lesions: Comparison with Gallium-67 Citrate

Department of Nuclear Medicine, Päijät-Häme Central Hospital, Lahti, Finland
Department of Nuclear Medicine, Turku University Central Hospital, Turku, Finland

Correspondence: For reprints contact: Martti Vorne, MD, Dept. of Nuclear Medicine, Päijät-Häme Central Hospital, SF-l5850 Lahti, Finland.

ABSTRACT

Forty-three patients with suspected benign, inflammatory, or infectious diseases were imaged with [^99mTc]HM-PAO-labeled leukocytes and [⁶⁷Ga]citrate. Technetium-99m leukocytes showed 22 true-positive, no false-positive, 19 true-negative, and two false-negative findings and [⁶⁷Ga]citrate 23, 7, 12 and 1, respectively. The sensitivity, specificity, and accuracy values with ^99mTc leukocytes were 92%, 100%, and 95%, and with [⁶⁷Ga]citrate 96%, 63%, and 81%. Technetium-99m leukocyte scintigraphy has a promising future in comparison with [⁶⁷Ga]citrate because of the ready availability of [^99mTc]HM-PAO, the good image quality, more rapid results (within few hours), and the lower radiation exposure to the patient with ^99mTc leukocytes. The usefulness of ^99mTc leukocytes in chronic osteomyelitis needs further evaluation.