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Regional Pulmonary Perfusion Following Human Heart-Lung Transplantation

Department of Nuclear Medicine, Division of Cardiovascular Surgery, and Division of Respiratory Medicine, Royal Victoria Hospital
Division of Cardiology, Sir Mortimer B. Davis Jewish General Hospital
Department of Physiology, McGill University, Canada

Correspondence: For reprints contact: Robert Lisbona, MD, Nuclear Medicine Department, Royal Victoria Hospital, 687 Pine Ave. West, Montreal Quebec, Canada H3A 1A1.

ABSTRACT

Ventilation and perfusion scans were obtained in six subjects who had undergone heart-lung transplantation with consequent denervation of the cardiopulmonary axis. Two of the subjects had developed obliterative bronchiolitis, which is believed to be a form of chronic rejection. Their pulmonary function tests demonstrated airflow obstruction and their scintigraphic studies were abnormal. In the remaining four subjects without obstructive airways disease, ventilation and planar perfusion scans were normal. Single photon emission computed tomography imaging of pulmonary perfusion in these patients revealed a layered distribution of blood flow indistinguishable from that of normal individuals. It is concluded that neurogenic mechanisms have little influence on the pattern of local pulmonary blood flow at rest.

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				S.M. Studer, R.D. Levy, K. McNeil, and J.B. Orens Lung transplant outcomes: a review of survival, graft function, physiology, health-related quality of life and cost-effectiveness Eur. Respir. J., October 1, 2004; 24(4): 674 - 685. [Abstract] [Full Text] [PDF]