HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maecke, H. R. Articles by Ritter, W. Search for Related Content PubMed PubMed Citation Articles by Maecke, H. R. Articles by Ritter, W.

The Molecular Structure of Indium-DTPA

Department of Nuclear Medicine, University Hospital, Basel and Institute of Inorganic Chemistry, University Basel, Basel, Switzerland

Correspondence: For reprints contact: Helmut R. Maecke, PhD, Dept. of Nuclear Medicine, University Hospital, CH-4031 Basel, Switzerland.

ABSTRACT

The x-ray structural characterization of Na₂In(DTPA). 7 H₂O is described. The structure is notable for two reasons. It is the first In³⁺-complex with relevance to antibody attachment to be structurally characterized. Surprisingly, the complex has coordination number eight and is the first monomeric In³⁺-complex with such a high coordination number. The potentially octadentate ligand binds through three amino groups and five deprotonated carboxylate groups to the metal ion. The ligand atoms surround the central indium atom in a slightly distorted Archimedian antiprismatic configuration. High resolution nuclear magnetic resonance studies in solution show that this high coordination number also pertains in aqueous medium. Consequently, one may conclude that octadentate ligands are optimal for the thermodynamic and kinetic stabilizationof In³⁺ in living systems. It is also indicated that bifunctional diethylenetriaminepentaacetic acid (DTPA) is superior to amide bound (=sevendentate) DTPA in antibody labeling.

This article has been cited by other articles:

				L. H. Pai-Scherf, J. A. Carrasquillo, C. Paik, O. Gansow, M. Whatley, D. Pearson, K. Webber, M. Hamilton, C. Allegra, M. Brechbiel, et al. Imaging and Phase I Study of 111In- and 90Y-labeled Anti-LewisY Monoclonal Antibody B3 Clin. Cancer Res., May 1, 2000; 6(5): 1720 - 1730. [Abstract] [Full Text]