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Comparison of Technetium-99m MIBI and Thallium-201 Chloride Myocardial Scintigraphy in Infants

Division of Nuclear Medicine, Department of Radiology and the Departments of Cardiology and Cardiovascular Surgery, The Children's Hospital and the Departments of Radiology, Pediatrics and Surgery, Harvard Medical School, Boston, Massachusetts

Correspondence: For reprints contact: S. Ted Treves, MD, Div. of Nuclear Medicine, The Children's Hospital, 300 Longwood Ave., Boston, MA 02115.

ABSTRACT

Myocardial perfusion scintigraphy was performed with both ²⁰¹Tl and a new six coordinate monocationic isonitrile complex of ^99mTc, [^99mTc]2-methoxyisobutylisonitrile (MIBI), on 11 infants who had undergone the arterial switch procedure for transposition of the great arteries. Unlike ²⁰¹Tl which can show rapid and variable rates of washout from myocardium, 73% of the initial first-pass activity of the isonitrile complex in the myocardium remains 1 hr after intravenous administration. The images obtained with [^99mTc]MIBI required a shorter recording time, entailed less radiation exposure to the patient, and were qualitatively at least as good as those obtained with ²⁰¹Tl. No infant had perfusion abnormalities. The potential applications of the isonitrile complexes for myocardial perfusion scintigraphy in children are discussed.

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