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Effect of Thallium-201 Blood Levels on Reversible Myocardial Defects

Department of Medicine and Department of Medicine/Radiology, Oregon Health Sciences University
Portland Veterans Administration Hospital, Portland, Oregon

Correspondence: For reprints contact: Richard A. Wilson, MD, Div. of Cardiology L462, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201.

ABSTRACT

To determine if ²⁰¹Tl plasma blood levels correlate with the presence of reversible myocardial defects during exercise testing, 14 patients with stable coronary artery disease underwent two separate exercise ²⁰¹Tl stress tests. Between initial and delayed imaging, on one test the patients drank an instant breakfast drink (eating) and on the other they drank an equivalent volume of water as a control (H₂O). Thallium-201 imaging was performed immediately postexercise, immediately after eating/H₂O and 210 min after eating/H₂O. Between initial and immediate post eating/H₂O images ²⁰¹Tl reversible defects occurred in 27/38 regions in the H₂O test versus 15/38 regions in the eating test (p = 0.02). Over this early time period, plasma ²⁰¹Tl activity was significantly higher in the H₂O test than eating test (p < 0.05). In conclusion, early reversal of ²⁰¹Tl defects may, in part, be the result of higher plasma ²⁰¹Tl activity early after initial postexercise ²⁰¹Tl imaging.

FOOTNOTES

^* Present address: Dept. of Medicine, University of Virginia, Charlottesville, VA.

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