HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Titelbaum, D. S. Articles by Martinez, F. J. Search for Related Content PubMed PubMed Citation Articles by Titelbaum, D. S. Articles by Martinez, F. J.

Renal Uptake of Technetium-99m Methylene Diphosphonate Following Therapeutic Radiation for Vertebral Metastases

Departments of Radiology and Radiation Therapy, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Department of Nuclear Medicine, Victoria Hospital, London, Ontario, Canada

Correspondence: For reprints contact: Barbara Fowble, MD, Dept. of Radiation Therapy, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104.

ABSTRACT

Radionuclide bone scans in two patients with breast cancer and concurrent chemotherapy treatment revealed increased band-like uptake of [^99mTc]methylene diphosphonate along the medial upper renal cortex corresponding to the portions of the kidneys included within the radiation field. The latency of onset of abnormal uptake was 5 to 9 mo following completion of radiation in one patient, peaked near 13 to 14 mo for both patients, and returned to baseline after 20 to 27 mo. Transient serum creatinine level elevations were also detected. These findings suggest that transient subclinical renal impairment may occur and be detected on bone scans following inadvertent inclusion of renal cortex in radiation fields.