| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
McConnell Brain Imaging Centre, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Correspondence: For reprints contact: E. Meyer, PhD, McConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 University St., Montreal, Quebec, Canada H3A 2B4.
ABSTRACT
The difference in tracer arrival times between the radial artery and the brain following i.v. injection of 15O-labeled water plus the difference in dispersion of the tracer bolus between these two sites have to be accounted for in order to quantify cerebral blood flow by the autoradiographic approach and positron emission tomography (PET). We describe a method that simultaneously corrects for these two effects by means of a four-parameter fit to the dynamically acquired data. Unlike with other methods, where the two corrections are performed sequentially, no additional measurement of the dispersion time constant is required. We have validated and tested the method by means of simulations and application to data from six human studies. The mean dispersion time constant of 4.0 ± 1.2 sec, estimated by the new method for the six studies, is in fair agreement with estimates of 3 to 5 sec derived from cardiac PET.
This article has been cited by other articles:
|
|
 |
|
  H. Okazawa, H. Yamauchi, H. Toyoda, K. Sugimoto, Y. Fujibayashi, and Y. Yonekura Relationship Between Vasodilatation and Cerebral Blood Flow Increase in Impaired Hemodynamics: A PET Study with the Acetazolamide Test in Cerebrovascular Disease J. Nucl. Med., December 1, 2003; 44(12): 1875 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Rose, F. M. Behm, E. C. Westman, R. J. Mathew, E. D. London, T. C. Hawk, T. G. Turkington, and R. E. Coleman PET Studies of the Influences of Nicotine on Neural Systems in Cigarette Smokers Am J Psychiatry, February 1, 2003; 160(2): 323 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Okazawa and M. Vafaee Effect of Vascular Radioactivity on Regional Values of Cerebral Blood Flow: Evaluation of Methods for H215O PET to Distinguish Cerebral Perfusion from Blood Volume J. Nucl. Med., July 1, 2001; 42(7): 1032 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nahmias, L. M. Wahl, S. Amano, M.-C. Asselin, and R. Chirakal Equilibration of 6-[18F]Fluoro-L-m-Tyrosine Between Plasma and Erythrocytes J. Nucl. Med., October 1, 2000; 41(10): 1636 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Nabavi, A. Cenic, R. A. Craen, A. W. Gelb, J. D. Bennett, R. Kozak, and T.-Y. Lee CT Assessment of Cerebral Perfusion: Experimental Validation and Initial Clinical Experience Radiology, October 1, 1999; 213(1): 141 - 149. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Naito, H. H. Ehrsson, S. Geyer, K. Zilles, and P. E. Roland Illusory Arm Movements Activate Cortical Motor Areas: A Positron Emission Tomography Study J. Neurosci., July 15, 1999; 19(14): 6134 - 6144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nariai, M. Senda, K. Ishii, S. Wakabayashi, T. Yokota, H. Toyama, Y. Matsushima, and K. Hirakawa Posthyperventilatory Steal Response in Chronic Cerebral Hemodynamic Stress : A Positron Emission Tomography Study Stroke, July 1, 1998; 29(7): 1281 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bodegard, A. Ledberg, S. Geyer, E. Naito, K. Zilles, and P. E. Roland Object Shape Differences Reflected by Somatosensory Cortical Activation J. Neurosci., January 1, 2000; 20(1): RC51 - RC51. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
