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Beta Dose Point Kernels for Radionuclides of Potential Use in Radioimmunotherapy

Department of Physics, McMaster University, and Hamilton Regional Cancer Centre, Ontario Cancer Foundation, Hamilton, Ontario, Canada

Correspondence: For reprints contact: C. S. Kwok, PhD, Hamilton Regional Cancer Centre, Ontario Cancer Foundation, 711 Concession St., Hamilton, Ontario, L8V 1C3, Canada.

ABSTRACT

Beta dose point kernels for ³²P, ⁶⁷Cu, ⁹⁰Y, ¹³¹I, ¹⁸⁶Re, and ¹⁸⁸Re nuclides appropriate for radioimmunotherapy are calculated based upon Monte Carlo results. The calculations are shownto differ significantly from values based upon solutions to the electron transport equation. Agreement with experiment for ³²P is found to be improved for the former as compared with the latter. Values of the scaled dose point kernels are tabulated at 4% intervals of the continuous slowing down approximation range for each of the six radionuclides. Beta dose distributions are also tabulated at corresponding distances from the source. This data may be used to calculate the spatial dose distribution expected following administration of radiolabeled monoclonal antibodies, aiding in optimum selection of the appropriate radionuclide. Parameters for functions providing analytic representation of the calculated scaled dose point kernels of individual beta groups are presented.

FOOTNOTES

W. V. Prestwich, PhD, Dept. of Physics, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.

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