HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lee, H.-B. Articles by Blaufox, M. D. Search for Related Content PubMed PubMed Citation Articles by Lee, H.-B. Articles by Blaufox, M. D.

Technetium-99m MAG-3 Clearances After Captopril in Experimental Renovascular Hypertension

Department of Nuclear Medicine Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York

Correspondence: For reprints contact: M. Donald Blaufox, MD, PhD, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York 10461.

ABSTRACT

Rats with one kidney clamped (2K1C), both kidneys clamped (2K2C), unilaterally nephrectomized with remaining kidney clamped (1K1C), and normals, were studied using ^99mTc mercaptoacetyltriglycine ([^99mTc]MAG-3) and ¹³¹I orthoiodohippurate ([¹³¹I]OIH). Clearances of [^99mTc]MAG-3 and [¹³¹I]OIH were performed after constricted rats became hypertensive. Clearances were repeated after i.v. Captopril. Clearances of [^99mTc]MAG-3 and [¹³¹I]OIH in normals didn't change significantly after Captopril. Clearances of [^99mTc]MAG-3 and [¹³¹I]OIH decreased insignificantly after Captopril in the 2K2C model. In the 2K1C group, normal kidney clearance increased ([^99mTc]MAG-3 p < 0.01 and [¹³¹I]OIH p < 0.025) and clamped kidney clearance decreased after inhibition ([^99mTc]MAG-3, p < 0.01, [¹³¹I]OIH p < 0.02). Clearances increased in the 1K1C group after Captopril ([^99mTc]MAG-3 p < 0.0025 and [¹³¹I]OIH, p < 0.001). The ratio of [^99mTc]MAG-3 to [¹³¹I]OIH before Captopril was 0.81 and 0.84 after Captopril. Changes in renal function after Captopril depend on the model of renovascular hypertension and possibly the dose administered. Technetium-99m MAG-3 clearance parallels [¹³¹I]orthoiodohippurate in renovascular hypertension.