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Osmium-191/Iridium-191m Generator Based on Silica Gel Impregnated with Tridodecylmethylammonium Chloride

Radiopharmaceuticals Department, Soreq Nuclear Research Center, Yavne 70600
Division of Nuclear Medicine, Beilinson Hospital, Sackler School of Medicine, Tel-Aviv University, Petah Tiqwe, Israel

Correspondence: For reprints contact: David Issachar, PhD, Radiopharmaceuticals Dept., Soreq Nuclear Research Center, Yavne 70600, Israel.

ABSTRACT

A new separation system for an ¹⁹¹Os/^191mIr generator is described. The system is composed of two columns in a series: a main column, packed with silica gel impregnated with tridodecylmethylammonium chloride (loaded with high activity ¹⁹¹Os as an osmyl chloride); and a scavenger column, packed with activated charcoal. Iridium-191m is eluted from the generator by pH 1 saline. For clinical use the eluate is buffered by succinate solution before injection. This new system is characterized by high performance ( 25% ^191mIr recovery with 5 x 10^–4% ¹⁹¹Os breakthrough) and long shelf-life (3 wk). The buffered eluate is sterile, pyrogen-free, and nontoxic, and contains no ¹⁹²Ir. It is suitable for first-pass radionuclide angiocardiography with a very low radiation dose to the patient.