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Quantification of Leg Muscle Perfusion Using Thallium-201 Single Photon Emission Computed Tomography

Department of Radiology, Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan

Correspondence: For reprints contact: Motoo Oshima, MD, Dept. of Radiology, Nagoya University School of Medicine, Showaku Nagoya, 466, Japan.

ABSTRACT

The purpose of this study is to quantify leg muscle perfusion with ²⁰¹Tl single photon emission computed tomography (SPECT). Six normal controls and 21 patients with peripheral arterial disease underwent this examination. Thallium-201 leg SPECT of both stress and redistribution was performed using a dual-headed digital gamma camera. Each slice of transverse images was normalized with pixels and whole-body counts. In normal controls, the activity of posterior tibial muscle components was significantly higher than that of anterior tibial muscle components (p < 0.001). In 14 components, where patients had insignificant lesions, profile curves were normal in 10 (71%). In 62 components, where patients had arteriographically significant lesions, stress profile curves were abnormal in 57 (92%) compared with normal controls. Approximately, in half (28/62) components which had significant lesions, profile curves showed redistribution after 3 hr compared with normal redistribution curves. In three patients who underwent successful bypass graftings, the activity of each muscle component returned to a normal range.

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