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Radiolabeled, Nonspecific, Polyclonal Human Immunoglobulin in the Detection of Focal Inflammation by Scintigraphy: Comparison with Gallium-67 Citrate and Technetium-99m-Labeled Albumin

Infectious Disease Unit of the Medical Service and the Division of Nuclear Medicine of the Department of Radiology of the Massachusetts General Hospital, Departments of Medicine and Radiology, Harvard Medical School, Boston, MA
The Cambridge Research Laboratory, Cambridge, MA and Ortho Biotech Imaging Products, Washington Crossing, New Jersey

Correspondence: For reprints contact: Robert H. Rubin, MD, Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114.

ABSTRACT

The accumulation of nonspecific polyclonal human immunoglobulin (IgG) radiolabeled with ¹²⁵I or ¹¹¹In was compared to that of [⁶⁷Ga]citrate and [^99mTc]albumin in rats with deep thigh inflammation due to Escherichia coli infection. Serial scintigrams were acquired at 1, 3, 24, and in some cases, 48 hr after injection. As early as 3 hr postinjection, [¹¹¹In]IgG showed greater accumulation at the lesion than [^99mTc]HSA (p < 0.01). Both [¹²⁵I]IgG and [¹¹¹In]IgG showed greater accumulation than [⁶⁷Ga]citrate (p < 0.01). At 24 hr, IgG image definition increased, while HSA image definition decreased, and the intensity of accumulation of both IgG preparations was greater than that of [⁶⁷Ga]citrate or [^99mTc]HSA (p < 0.01). At all imaging times, [⁶⁷Ga]citrate accumulation was surprisingly low. In inflammation produced by Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, or turpentine, [¹¹¹In]IgG accumulation was similar to the results obtained with Escherichia coli. These studies suggest that focal sites of inflammation can be detected with radiolabeled nonspecific human polyclonal IgG.

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