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Synthesis, Characterization, and Biodistribution of [^113mIn]TE-BAT: A New Myocardial Imaging Agent

Department of Chemistry, Beijing Normal University, Beijing, China
Department of Radiology, University of Pennsylvania, Philadelphia

Correspondence: For reprints contact: Hank F. Kung, PhD, Div. of Nuclear Medicine, Dept. of Radiology, University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104.

ABSTRACT

In order to develop a new myocardial perfusion agent, new lipid-soluble complexes containing a net charge of +1 were evaluated. Synthesis, radiolabeling, characterization, and biodistribution of a unique indium complex, [^113mIn]TE-BAT (tetraethyl-bis-aminoethanethiol), are described. The complex formation between In⁺³ and TE-BAT ligand is rapid, simple, and of high yield ( 95%). This process is amenable to kit formulation. The complex has a net charge of +1 and an In/ligand ratio of 1:1. Biodistribution in mice shows higher heart uptake and longer retention as compared to ²⁰¹Tl. This complex, when labeled with ¹¹¹In, shows promise as a possible tracer for myocardial perfusion imaging.