JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 30 No. 2 209-215
© 1989 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zielinski, J. E.
Right arrow Articles by Hochberg, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zielinski, J. E.
Right arrow Articles by Hochberg, R. B.

The Synthesis of 11ß-Methoxy-[16{alpha}-123I] Iodoestradiol and Its Interaction with the Estrogen Receptor In Vivo and In Vitro

Jan E. Zielinski, Janice M. Larner, Paul B. Hoffer and Richard B. Hochberg

Departments of Obstetrics and Gynecology and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut

Correspondence: For reprints contact: Richard B. Hochberg, PhD, Yale University School of Medicine, PO Box 3333, New Haven, CT 06510.

ABSTRACT

In order to produce an estrogen receptor mediated imaging agent, we have synthesized 11ß-methoxy-16{alpha}-iodoestradiol labeled with 123I, and have studied its interaction with the estrogen receptor and its distribution in rats and rabbits. This 123I-labeled steroid, 11ß-methoxy-16{alpha}-[123I]iodoestradiol, binds with high affinity, Ka = 6 x 109 M–1, and specificity to the estrogen receptor in uterine cytosol. When tested in vivo, this radiolabeled steroid concentrates by a receptor mediated mechanism, in the estrogen target tissue, the uterus, producing very high target to nontarget tissue ratios. The results of these experiments indicate that 11ß-methoxy-16{alpha}-[123I]iodoestradiol may be a useful imaging agent for clinically monitoring and detecting estrogen receptor containing tumors.




This article has been cited by other articles:


Home page
 JNMHome page
D. A. Mankoff, J. M. Link, H. M. Linden, L. Sundararajan, and K. A. Krohn
Tumor Receptor Imaging
J. Nucl. Med., June 1, 2008; 49(Suppl_2): 149S - 163S.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1989 by the Society of Nuclear Medicine.