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Regional Left Ventricular Filling: Does It Reflect Diastolic Abnormalities in Contiguous Areas of Myocardium?

Cardiovascular Division of the Department of Medicine and the Nuclear Medicine Division of the Department of Radiology, State University of New York Health Sciences Center, Stony Brook, New York
Department of Physics, Kenyon College, Gambier, Ohio

Correspondence: For reprints contact: Edward J. Brown, Jr., MD, Cardiology Division, Health Sciences Center T17-020, SUNY at Stony Brook, Stony Brook, NY 11794.

ABSTRACT

To test the hypothesis that regional left ventricular filling reflects diastolic changes in contiguous areas of myocardium, we performed radionuclide ventriculograms on normal subjects, patients with left anterior descending coronary artery disease, and patients with anteroseptal myocardial infarctions. We reasoned that because diastolic properties of the anteroseptal myocardium should be different in the three groups of patients, regional filling in the anteroseptal area of the left ventricle should also be different, if regional filling does, indeed, reflect diastolic changes in the adjacent myocardium. While anteroseptal regional filling in the normal subjects was different than regional filling in the two patient groups, the degree of filling abnormality was similar in patients with and without myocardial infarctions. Our results suggest that regional left ventricular filling is not exclusively determined by diastolic changes in contiguous areas of myocardium.