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Estimation of Technetium-99m-MAG₃ Plasma Clearance in Adults from One or Two Blood Samples

Division of Nuclear Medicine
University of Alabama in Birmingham, and Birmingham V.A. Medical Center, Birmingham, Alabama
Division of Nuclear Medicine, Emory University, Atlanta, Georgia

Correspondence: For reprints contact: Charles D. Russell, MD, PhD, Div. of Nuclear Medicine, University of Alabama Hospital, Birmingham, AL 35233.

ABSTRACT

Technetium-99m mercaptoacetyltriglycine (MAG₃) clearance is strongly correlated with effective renal plasma flow and can be used directly as a measure of renal function. For these reasons, formulas were developed for estimation of [^99mTc]MAG₃ clearance based on one or two plasma samples. A two-exponential model provided an excellent fit for 8-point plasma clearance curves obtained from 35 patients having a wide range of renal function. The 8-point [^99mTc]MAG₃ clearance could be estimated from a single point at 43 min with an error of 19 ml/min (residual s.d.) or from two samples at 12 and 94 min with an error of 7 ml/min. The relative errors with MAG₃ are thus comparable to those reported for similar techniques used with [¹³¹I]orthoiodohippurate, [^99mTc]diethylenetriaminepentraacetic acid and [⁵¹Cr] ethylenediaminetetraacetic acid.

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