HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hatazawa, J. Articles by Seo, S. Search for Related Content PubMed PubMed Citation Articles by Hatazawa, J. Articles by Seo, S.

Quantitative Evaluation of L-[Methyl-C-11] Methionine Uptake in Tumor Using Positron Emission Tomography

Division of Nuclear Medicine, Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Department of Neurosurgery, Tohoku University, School of Medicine, Department of Radiology and Nuclear Medicine, Research Institute for Tuberculosis and Cancer, Tohoku University

Correspondence: For reprints contact: Jun Hatazawa, MD, PhD, Cyclotron and RI Center, Tohoku University, Aramaki Aoba, Sendai, Japan.

ABSTRACT

Tumor uptake of L-[methyl-¹¹C]methionine ([¹¹C]Met) was assessed in six patients with brain tumors and three patients with lung cancer using positron emission tomography (PET). In arterial plasma samples taken at 5, 15, 30, and 60 min after injection, a fraction of [¹¹C]Met was measured using high performance liquid chromatography in individual patients. Employing curve fitting, a history of [¹¹C]Met activity was obtained as an input function. By means of sequential PET scannings and graphic analysis, uptake rate and distribution volume of [¹¹C]Met in tumor tissue were calculated. In two studies irreversible uptake into the tumors was not seen when total plasma ¹¹C activity was used as the input; however when[¹¹C]Met plasma activity was used, definite irreversible uptake was seen, indicating tumor viability. In other studies, up to 24% underestimation of uptake rate was found. The present results demonstrated the importance of measuring [¹¹C]Met in plasma for quantitative assessment of in vivo amino acid metabolism in tumors.

This article has been cited by other articles:

				C. Schiepers, W. Chen, T. Cloughesy, M. Dahlbom, and S.-C. Huang 18F-FDOPA Kinetics in Brain Tumors J. Nucl. Med., October 1, 2007; 48(10): 1651 - 1661. [Abstract] [Full Text] [PDF]

				N. Pandit-Taskar Oncologic Imaging in Gynecologic Malignancies J. Nucl. Med., November 1, 2005; 46(11): 1842 - 1850. [Abstract] [Full Text] [PDF]

				K Miwa, J Shinoda, H Yano, A Okumura, T Iwama, T Nakashima, and N Sakai Discrepancy between lesion distributions on methionine PET and MR images in patients with glioblastoma multiforme: insight from a PET and MR fusion image study J. Neurol. Neurosurg. Psychiatry, October 1, 2004; 75(10): 1457 - 1462. [Abstract] [Full Text] [PDF]