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Pharmacokinetics of Thallium-201 in Normal Individuals After Routine Myocardial Scintigraphy

Institute of Medicine, Nuclear Research Center Jüelich, Jüelich, FRG

Correspondence: For reprints contact: Hans Herzog, PhD, Institute of Medicine, Nuclear Research Center Jülich, P.O.B. 1913, D-5170 Jülich, Federal Republic of Germany.

ABSTRACT

Data of pharmacokinetic distribution of and radiation dose from ²⁰¹Tl chloride used in routine myocardial scintigraphy are based on animal studies or on small groups of humans not exercised. In order to obtain data under routine conditions pharmacokinetics of ²⁰¹Tl were measured in 15 individuals who had undergone diagnostic myocardial scintigraphy and were classified as normal. Ventral and dorsal whole-body scans were acquired until 9 days after injection. Conjugate pixels were averaged geometrically. Percentage values of total administered dose were obtained for total body and 13 organs by using a calculation method that takes into account the differentiation of overlapping organs.

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