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The Journal of Nuclear Medicine Vol. 29 No. 9 1577-1581
© 1988 by Society of Nuclear Medicine
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Evaluation of Cyclosporine Nephrotoxicity in Rats with Various Renal Radioactive Agents

John G. McAfee, F. Deaver Thomas, Gopal Subramanian, Marsha Roskopf and Bradford Hellwig

Division of Nuclear Medicine and Radiological Sciences, Department of Radiology, SUNY Health Science Center at Syracuse, Syracuse, New York

Correspondence: For reprints contact: John G. McAfee, MD, Div. of Nuclear Medicine and Radiological Sciences, Dept. of Radiology, SUNY Health Science Center at Syracuse, 750 East Adams St., Syracuse, NY.

ABSTRACT

The efficacy of different radiodiagnostic agents for demonstrating the decline in renal function from cyclosporine (CyA) nephrotoxicity was assessed in rats receiving a standard dose of the drug for 2 wk, compared with control rats. The agents included [99mTc]DTPA, [131I]hippuran, [111In]lysozyme, [99mTc]glucoheptonate (GHA), [99mTc]dimercaptosuccinate (DMS) and [111In] aminated dextran (amdex). A small dose of [99mTc]-or [111In]DTPA was administered simultaneously to normalize the results for variations in drug response from one animal to another. There were statistically significant differences in the detectability of the renal functional impairment by plasma clearance, early and 2-hr renal uptake among the different agents. However, none was clearly superior to DTPA. This conclusion is consistent with previous studies which showed a parallel decline in glomerular filtration rate (GFR) and effective renal plasma flow in acute CyA toxicity probably due primarily to vasoconstriction.






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Copyright © 1988 by the Society of Nuclear Medicine.