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Kinetic Analysis of Technetium-99m d,1-HM-PAO Decomposition in Aqueous Media

Department of Radiology, University of Missouri-Columbia and Nuclear Medicine Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri

Correspondence: For reprints contact: Joseph C. Hung, PhD, Diagnostic Nuclear Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

ABSTRACT

Technetium-99m-d,1-hexamethylpropyleneamine oxime[⁹⁹Tc]d,1-HM-PAO) is a neutral-lipophilic chelate formed from a kit in high yield by stannous reduction of Na⁹⁹TcO₄^–. Of three methods used to analyze the purity of the ^99mTc complexes, a single strip method using either as the developing solvent was the most rapid and simple to perform. The lipophilic chelate converts to ^99mTcO₄^– and other hydrophilic products with time and this limits the useful lifetime of the preparations. The rate of decomposition of [^99mTc]d,1-HM-PAO increased in the presence of excess stannous ion and at pH >9.

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