| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Radiotherapy, Medicine, and Radiology, Division of Nuclear Medicine, University Central Hospital of Turku
Turku Medical Cyclotron Project, Turku; Finland
Correspondence: For reprints contact: Heikki Minn, MD, Dept. of Radiotherapy, University of Turku, SF-20520 Turku, Finland.
ABSTRACT
Nineteen patients with malignant head and neck tumors were imaged before and during radiation therapy with 18F-2-fluoro-2-deoxy-D-glucose (FDG) to study the effect of radio therapy (RT) on FDG uptake. All tumor images were FDG-positive before treatment. After RT, a decrement of tumor FDG uptake was found in all but two patients; these were nonradioresponders. There was a significant decrement (p < 0.001) in uptake ratios after irradiation of 30 ± 5 Gy among the radioresponsive (CR + PR) but not among the radioresistant (NC + PD) tumors. The administered dose of RT correlated (r = 0.47, p < 0.05) with the decrement in FDG activity among the CR + PR but not among the NC + PD patients. The biologic half-life of FDG radioactivity in tumor tissue was evaluated by dynamic scintigraphy. A change in the half-life of FDG toward the value observed in normal tissue was associated with treatment response. The results suggest that FDG imaging can be used for follow-up of RT in patients with head and neck cancer.
This article has been cited by other articles:
|
|
 |
|
  M. B. Fukui, T. M. Blodgett, C. H. Snyderman, J. J. Johnson, E. N. Myers, D. W. Townsend, and C. C. Meltzer Combined PET-CT in the Head and Neck: Part 2. Diagnostic Uses and Pitfalls of Oncologic Imaging RadioGraphics, July 1, 2005; 25(4): 913 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Wieder, B. L.D.M. Brucher, F. Zimmermann, K. Becker, F. Lordick, A. Beer, M. Schwaiger, U. Fink, J. R. Siewert, H. J. Stein, et al. Time Course of Tumor Metabolic Activity During Chemoradiotherapy of Esophageal Squamous Cell Carcinoma and Response to Treatment J. Clin. Oncol., March 1, 2004; 22(5): 900 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G J R Cook Nuclear medicine in imaging head and neck malignancies Imaging, September 1, 2003; 15(3): 141 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kitagawa, S. Nishizawa, K. Sano, T. Ogasawara, M. Nakamura, N. Sadato, M. Yoshida, and Y. Yonekura Prospective Comparison of 18F-FDG PET with Conventional Imaging Modalities (MRI, CT, and 67Ga Scintigraphy) in Assessment of Combined Intraarterial Chemotherapy and Radiotherapy for Head and Neck Carcinoma J. Nucl. Med., February 1, 2003; 44(2): 198 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Spence, M. Muzi, M. M. Graham, F. O'Sullivan, J. M. Link, T. K. Lewellen, B. Lewellen, S. D. Freeman, D. A. Mankoff, J. F. Eary, et al. 2-[18F]Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas before and after Radiotherapy: Correlation with Outcome Clin. Cancer Res., April 1, 2002; 8(4): 971 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Ahuja, S. S. Y. Ho, S. F. Leung, J. Kew, and C. Metreweli Metastatic Adenopathy from Nasopharyngeal Carcinoma: Successful Response to Radiation Therapy Assessed by Color Duplex Sonography AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 151 - 156. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. Romer, A.-R. Hanauske, S. Ziegler, R. Thodtmann, W. Weber, C. Fuchs, W. Enne, M. Herz, C. Nerl, M. Garbrecht, et al. Positron Emission Tomography in Non-Hodgkin's Lymphoma: Assessment of Chemotherapy With Fluorodeoxyglucose Blood, June 15, 1998; 91(12): 4464 - 4471. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
