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Technetium-99m HM-PAO-SPECT Study of Regional Cerebral Perfusion in Early Alzheimer's Disease

Department of Biomedical Technologies, H. S. Raffaele, University of Milan
Department of Neuroscience, University of Rome
Clinica Neurologica II, Policlinico Hospital, University of Milan
Department of Environmental Sciences, University of L'Aquila, Italy

Correspondence: For reprints contact: Daniela Perani, Dept. of Biomedical Technologies, Nuclear Medicine, Istituto San Raffaele, University of Milan, Via Olgettina 60, 20132 Milan, Italy.

ABSTRACT

Regional cerebral perfusion was evaluated by single photon emission computed tomography (SPECT) using technetium-99m hexamethylpropyleneamine oxime ([^99mTc]HM-PAO) in sixteen patients with Alzheimer's disease (AD) in early clinical phase and in 16 healthy elderly controls. In all patients transmission computed tomography (TCT) and/or magnetic resonance imaging (MRI) did not show focal brain abnormalities. Relative to normal subjects, AD patients showed significant reductions in cortical/cerebellar activity ratio: cortical perfusion was globally depressed with the largest reductions in frontal and posterior temporo-parietal cortices. Asymmetries of relative perfusion between cerebral hemispheres were also demonstrated when language was affected or visuospatial functions were unevenly impaired. In patients with early AD, SPECT provides functional information to be compared with clinical and psychometric data.

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