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Sipple's Syndrome with Liver Tumors Examined by Iodine-131 MIBG and Technetium-99m(V)-DMSA

Department of Nuclear Medicine and Surgery, Kyoto University School of Medicine, Kyoto
Shinkori Hospital, Osaka, Japan

Correspondence: For reprints contact: Hitoya Ohta, Dept. of Nuclear Medicine, Kyoto University Hospital, 54 Shogoin-Kawaharacho, Sakyoku Kyoto 606 Japan.

ABSTRACT

This case report describes the localization and categorization of tumors using ^99mTc(V)-dimercaptosuccinic acid and [¹³¹I]metaiodobenzylguanidine scans in a very uncommon case of medullary thyroid carcinoma associated with pheochromocytoma (Sipple's syndrome) and hepatocellular carcinoma. Technetium-99m(V)-dimercaptosuccinic acid showed accumulation only in medullary thyroid carcinoma, but [¹³¹I]metaiodobenzylguanidine scans were positive in both medullary thyroid carcinoma and pheochromocytoma. In advanced Sipple's syndrome, combined use of [^99mTc(V)]dimercaptosuccinic acid and [¹³¹I] metaiodobenzylguanidine may be useful for the categorization of tumor mass lesions and planning appropriate therapy.