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Gallium-67 Citrate Localization in Osteoclast Nuclei of Paget's Disease of Bone

Departments of Basic Sciences, Medicine and Nuclear Medicine, University of Southern California and Orthopaedic Hospital, Los Angeles, California

Correspondence: For reprints contact: Barbara G. Mills, MD, Bone Physiology Laboratory, Orthopaedic Hospital, 2400 South Flower St., Los Angeles, CA 90007-2697.

ABSTRACT

Gallium-67 citrate scintigraphy has been used to indicate the extent of bone involvement in patients with Paget's disease of bone and is an excellent marker in monitoring the effects of specific therapy. Since gallium uptake is dependent on cellular function, autoradiographic techniques can be applied to cells of Paget's lesions to understand better the mechanism of [⁶⁷Ga]citrate uptake. Bone biopsies were obtained from sites of increased uptake using [⁶⁷Ga]citrate scintigraphy in two patients with Paget's disease. In both patients electron microscopic autoradiographs demonstrated a high concentration of silver grains over the nuclei of osteoclasts. The cellular mechanism is unknown but may be related to the known inhibitory effect of calcitonin on osteoclast activity. The association of [⁶⁷Ga]citrate with the nucleus of the osteoclasts is unique and different from tumor cells in which there is a high association of [⁶⁷Ga]citrate with the lysosome fraction within the cytoplasm.

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