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Ocular Radioimmunoscintigraphy: Sensitivity and Practical Considerations

Departments of Nuclear Medicine, and Ophthalmology St. Bartholomew's Hospital, London, EC1., UK

Correspondence: For reprints contact: J. Bomanji, MD, Dept. of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield, London EC1A, 7BE, UK.

ABSTRACT

Ocular radioimmunoscintigraphy was performed in 20 patients using ^99mTc-labeled monoclonal antibody 225.28S, F(ab')₂ fragments. Radioimmunoscintigraphy was positive in 13 patients and the diagnosis of ocular melanoma was confirmed by enucleation of the eye or clinical follow-up. Scintigraphy was positive in one patient with lymph node metastasis from an ocular melanoma. In six patients immunoscintigraphy was negative. Using this technique a sensitivity of 92.8% was achieved for detecting ocular melanomas. Single photon emission tomography helped to separate the lesions situated in the nasal quadrant of the eye from the adjacent nasopharangeal activity.With appropriate imaging techniques small tumors of the order of 3 x 5 x 3 mm could be detected clearly.