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Recommended Method for Indium-111 Platelet Survival Studies

Correspondence: For reprints contact: Dr. A. E. Ferrant, Dept. of Haematology, Cliniques Universitaires Saint Luc, Avenue Hippocrate 10-1744, B-1200 Brussels, Belgium.

Correspondence: Administrative correspondence to: Dr. S. M. Lewis, Royal Postgraduate Medical School, Ducane Rd., London W12 OHS, U.K. or Dr. R. L. Veriwilghen, University Hospital, Herestraat 49, B 3000 Leuven, Belgium.

ABSTRACT

Radioactive indium (¹¹¹In) has been introduced as an alternative to ⁵¹Cr as a platelet label because of its shorter half-life, higher photon yield and greater affinity for platelets. Furthermore, platelet labelling with ¹¹¹In is possible at lower platelet counts than with ⁵¹Cr. In healthy individuals, the kinetics of simultaneously injected ¹¹¹In-labeled and ⁵¹Cr-labeled platelets are similar. The document describes the technical and analytic aspects of platelet survival determination with ¹¹¹In-labeled platelets and is intended to supplement the previously published recommendations for platelet survival studies.

FOOTNOTES

^* Prepared by the ICSH Expert Panel on Diagnostic Applications of Radionuclides (R. F. Schilling (Chairman), A. Ferrant (Secretary), I. Cavil, R. D. Ganatra (IAEA), L. A. Harker, A. du P. Heyns, S. M. Lewis, C. A. Ludlam, A. M. Peters) and has been approved by the ICSH Board for publication as an ICSH standard.

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