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The Journal of Nuclear Medicine Vol. 29 No. 4 561-563
© 1988 by Society of Nuclear Medicine
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Paget's Disease: A Cause of Photopenic Skeletal Defect in Indium-111 WBC Scintigraphy

Eddy K. Dunn, Rafael A. Vaquer and Arnold M. Strashun

Division of Nuclear Medicine, Department of Radiology, SUNY Health Science Center at Brooklyn

Correspondence: For reprints contact: Eddy K. Dunn, MD, Box 1210, SUNY Health Science Center at Brooklyn, 450 Clarkson Ave., Brooklyn, NY 11203.

ABSTRACT

As an incidental finding in an [111In]WBC scan performed in search of an infectious focus, photon deficient areas were found in several skeletal locations, characterized by bone and gallium scintigraphy and confirmed radiographically as sites of active Paget's disease. The literature concerning cold bone defects in the [111In]WBC scintiscan is reviewed. Loss of marrow component in the bone appears to be the underlying mechanism for such an abnormality.






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Copyright © 1988 by the Society of Nuclear Medicine.