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Comparison of Different Radioactive Agents for the Detection of Renovascular Hypertension with Captopril in a Rat Model

Division of Nuclear Medicine and Radiological Sciences, Department of Radiology, and Department of Medicine SUNY Health Science Center at Syracuse, Syracuse, New York

Correspondence: For reprints contact: John G. McAfee, MD, Div. of Nuclear Medicine and Radiological Sciences, Dept. of Radiology, and Dept. of Medicine, SUNY Health Science Center at Syracuse, 750 E. Adams St., Syracuse, NY.

ABSTRACT

In Goldblatt hypertension in rats produced by implanting a silver clip on the left renal artery, captopril induces a greater difference in the 1-min uptake of diethylenetriaminepentaacetic acid (DTPA) between the two kidneys than in baseline uptakes, similar to the experiences in unilateral renovascular hypertension in man. The combination of captopril and furosemide induces an even greater difference in renal uptakes than with captopril alone in this rat model. In paired experiments, DTPA complexes were used as a standard to compare the differences in renal uptake between the two kidneys after captopril-furosemide with other existing and potential renal radiodiagnostic agents. No statistically significant difference was found between DTPA, glucoheptonate, dimercaptosuccinic acid, aminated dextran, or lysozyme. However, the differences in renal uptake were significantly less with hippuran than with DTPA. Furosemide and captopril caused delayed renal retention of hippuran after one minute. This response appeared to be due to non-specific volume depletion because it occurred in both clipped and unclipped kidneys.