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Iodine-125 Cholesteryl Iopanoate for Measuring Extent of Atherosclerosis in Rabbits

Departments of Pharmacology and Internal Medicine, Division of Nuclear Medicine, University of Michigan Medical School and Veteran's Administration Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: Raymond E. Counsell, PhD, Dept. of Pharmacology, M6322 Medical Science Building I, University of Michigan Medical School, Ann Arbor, MI 48109-0626.

ABSTRACT

Rabbits rendered atherosclerotic by mechanical aortic de-endothelialization and 6 wk of cholesterol feeding were administered estradiol-17 ß-cypionate, an anti-atherogenic agent in rabbits. These animals were compared to a similar, untreated group and control animals fed a regular non-atherogenic diet. Iodine-125 cholesteryl iopanoate ([¹²⁵I]CI), a nonhydrolyzable cholesteryl ester derivative, was administered intravenously at regular intervals throughout the study. Six days after the last dose of [¹²⁵I]CI, the animals were scanned with a gamma camera. After animals were killed, tissue distribution of the ¹²⁵I radioactivity showed a significant decrease of [¹²⁵I]CI accumulation in the aorta of estrogen-treated as compared to untreated, cholesterol-fed animals. However, the accumulation of [¹²⁵I]CI in the aortas was insufficient to accurately define the presence of atheroma by gamma camera scintigraphy.

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