HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hamilton, D. Articles by Crowther, D. Search for Related Content PubMed PubMed Citation Articles by Hamilton, D. Articles by Crowther, D.

The Behavior of Autologous Indium-114m-Labeled Lymphocytes in Patients with Lymphoid Cell Malignancy

Regional Department of Medical Physics and Bioengineering, CRC Department of Medical Oncology, Department of Radiotherapy, Christie Hospital and Holt Radium Institute; Manchester
Department of Medical Biophysics, Department of Immunology, University of Manchester, England

Correspondence: For reprints contact: David Hamilton, PhD, Dept. of Medical Physics and Bioengineering, St James's Hospital, P.O. Box 580, Dublin 8, Ireland.

ABSTRACT

It has been shown that radioactive material can be localized to lymphocyte traffic areas using radiolabeled autologous lymphocytes and that ^114mIn deposited in such a way in rats produces a lymphopoenia by establishing a selective internal irradiation of circulating lymphocytes. The study reported here was undertaken to investigate the feasibility of using this technique in patients with lymphoid cell malignancy. Up to 22.7 MBq was administered to seven patients with active non-Hodgkin's lymphoma involving the spleen and the behavior of the radioactive material was followed over subsequent months. Estimates of the activity in peripheral blood, bone marrow, excrete samples, and of the variation in the whole-body distribution were obtained. The administered radioactive material cleared rapidly from the blood, 85% being removed within the first 30 mm. There was an almost immediate uptake of most of this by the spleen and liver with <5% of administered activity accumulating in the bone marrow. After 48 hr, the whole-body distribution changed only slowly and there was a regular decrease of the activity in the spleen. Excretion of radioactive material occurred via both the urine and feces and amounted to <1% of administered activity per day. This pharmacokinetic data was used to calculate radiation absorbed doses to various organs for a standard man. It is concluded that this represents a feasible technique for the targeting of radioactive material for the treatment of lymphoid malignancy.